Course: The Human Microbiome in Well being and Illness


In collaboration with the Primal Well being Coach Institute, I’ve put collectively a complete academic course on the microbiome known as The Human Microbiome in Well being and Illness. The course is designed for well being coaches to empower them in advising purchasers and sufferers on points microbiome. It’s, I consider, essentially the most complete and full course of its sort. Whereas designed for well being coaches, it may possibly additionally present deep schooling on all microbiome points for different well being professionals, physicians, or the well-informed citizen scientist or anybody with a deep curiosity in these essential points.

As a result of the science exploring the human microbiome is rising so quickly, most individuals in healthcare have develop into helplessly out-of-date. But insights into the microbiome are proving to be probably the most essential revolutions in well being to emerge in a few years. It’s altering virtually every little thing we thought we knew about well being and illness, re-defining well being situations as widespread as sort 2 diabetes, weight problems, hypertension, coronary heart illness, colon most cancers, and cognitive impairment.

The course is delivered over 9 modules, every beginning with a video overview, contains graphics and diagrams, well being teaching ideas, and chosen references for additional exploration. Observe that Members of my Internal Circle may even be offered entry to an analogous, expanded course near-future.

Right here is the final format of the course:

Module 1: Overview
Fundamental gastrointestinal (GI) anatomy and physiology from a microbiome perspective
Microbiome in well being—areas, concentrations, species: micro organism, archaea, fungi, viruses, phages
Microbiome in illness—major, secondary; causative or exacerbating roles; metabolites
Strategies of evaluation—stool microbiome evaluation; breath testing; empiric strategies
Why the science has progressed quickly simply over the previous decade—tradition strategies, 16s rRNA sequencing, shotgun metagenomics
Human Microbiome Challenge, Meta-HIT
Why examine the microbiome, what well being benefits are attainable?

Module 2: Fundamental microbiology
Micro organism, fungi, archaea, bacteriophages
Gram optimistic, Gram unfavorable
Asexual replica, fermentation
Lipopolysaccharide, lipoteichoic acid, beta glucan
Introduction to endotoxemia and translocation

Module 3: Human GI anatomy and physiology from a microbiome perspective
Mouth, tooth, oropharynx—salivary elements; reservoir of microbes in regular vs. decay/gingivitis/periodontitis
Esophagus—propulsive motion, esophageal sphincter
Abdomen—Position of abdomen acid, parietal cells, H pylori, intrinsic issue
Duodenum—widespread bile duct, cholecystokinin, alkalization, bile, pancreatic enzymes; susceptibility to microbial disruption
Jejunum, ileum—mucus barrier, intestinal immune system, myenteric nervous system, vagus nerve; distinctive microbial setting; migrating motor advanced—is that this an actual concern?
Colon—cecum, appendix, ascending, transverse, descending, sigmoid

Module 4: Gastrointestinal microbiome in well being
Is there such a factor as a “wholesome microbiome”? Judgements primarily based on assessments of indigenous hunter-gatherer populations—Do they characterize the optimum state of affairs or variations to native environments?
Wholesome trendy microbial populations—GI areas, concentrations, and capabilities of micro organism, fungi, archaea
Features—intestinal mucus stimulation, competitors with pathogens, meals processing, participation in intestinal immune perform
Quick-chain fatty acid metabolites
Vitamin metabolites—B nutritional vitamins, K2
Bile acid metabolites—position of taurine, glycine; bile salt hydrolase
Idea of keystone species and position in sustaining a wholesome microbiome
Evolution of the microbiome from start, to infancy, to early childhood, to maturity, to aged
Adjustments related to being pregnant and lactation
Fundamentals of gastrointestinal mucus

Module 5: The disrupted microbiome and its position in human illness
Core microbiota; relative populations of Bacteroidetes, Firmicutes, Actinobacteria, Proteobacteria, and Verrucomicrobia; modifications in species composition
Overgrowth of micro organism, fungi, archaea
Key markers—Bacteroidetes/firmicutes ratio; proportion Verrucomicrobia/Akkermansia; proportion Faecalibacterium prausnitzii; Fusobacterium nucleatum; Ruminococcaceae, Lachnospiraceae, Clostridia; Proteobacteria—E. coli, Klebsiella, Enterobacter, and so on.; Gram positives—Staphylococcus, Streptococcus, Enterococcus
Components that disrupt microbiome composition—antibiotics, different pharmaceuticals, meals components (emulsifiers, preservatives) herbicides/pesticides, glyphosate, chlorinated ingesting water, artificial sweeteners, stress, electromagnetic frequencies?
Penalties of lack of prebiotic fibers and different microbial vitamins
Adjustments in species location—colon vs small bowel, bacterial translocation
Disrupted microbial composition, disrupted intestinal mucus barrier, intestinal permeability, serum LPS, serum zonulin
Metabolic endotoxemia and its broad penalties
That means of meals intolerances—histamine containing meals, nightshades, FODMAPs, fructose, legumes, nuts

Module 6: The microbiome in numerous illness states
Gallstones and bacterial infestation
Pancreatic exocrine insufficiency
Gingivitis, periodontitis—together with the colon connection by way of Fusobacterium nucleatum as a reason for colon most cancers
Irritable bowel syndrome (IBD)
Inflammatory bowel illness
Celiac illness, “non-celiac gluten sensitivity”
Sort 2 diabetes, obese/weight problems
Autoimmune illnesses
Neurodegenerative illnesses
Heart problems
Problems of being pregnant and lactation
Bariatric procedures together with gastric bypass

Module 7: Strategies of microbiome evaluation
Symptom evaluation
Stool evaluation—reliability, strategies (16S rRNA vs. shotgun metagenomics), microbial analyses, physiologic markers. We evaluate a number of actual world examples throughout completely different testing platforms—e.g., Genova, Ombre, Viome, Intestine Zoomer.
Breath testing—hydrogen, methane, hydrogen sulfide, AIRE system, Trio-Good

Module 8: Deal with types of overgrowth
Small intestinal bacterial overgrowth (SIBO)—signs; endotoxemia, systemic illness implications; evaluation; eradication; prevention of recurrences
Small intestinal fungal overgrowth (SIFO)—signs; beta glucan, systemic illness implications; evaluation; eradication; prevention of recurrences
Intestinal methanogen overgrowth (IMO)—signs; evaluation; eradication

Module 9: Methods and instruments for microbiome administration
Probiotics–composition, rationale, ineffectiveness; future instructions
Fermented meals–offering the microbiome-”molding” results of essential fermenting species akin to Leuconostoc and Pediococcus species; fundamentals of fermentation
Prebiotic fibers, polysaccharides, polyphenols
Fecal transplant and associated strategies
Restoration of keystone species, higher GI colonization, bacteriocin manufacturing

Closing feedback, overview, future instructions
Assets to observe new developments
Assets for continued suggestions and help
Microbe sources for fermentation
Recipes for chosen microbial ferments

In case you are focused on enrolling on this course (it’s open to non-health coaches, additionally, in addition to docs, different well being professionals, or for anybody focused on an in depth dialogue concerning the microbiome), join right here.



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